Orlistat and pregnancy – Orlistat Pregnancy And Lactation
Since weight loss offers no potential benefit to a pregnant woman and may result in fetal harm, orlistat is contraindicated during pregnancy. When given to pregnant animals, the drug did not cause any problems. In all imaginable cases, this medication is not a good idea for pregnant women. Orlistat works by blocking the enzyme that breaks down fats in your diet. No causal relationship or physiopathological (mechanism >= hepatitis AND mechanism <= orlistattherapy has been established. Acute kidney injury was associated temporally with an increased dosage of orlistat therapy and the development of increased fat malabsorption. They are the natural effects of orlistat's fat-blocking action and are actually signs that the medication is working properly.
Orlistat Xenical eMedExpert com
Stop taking orlistat and tell your doctor right away if you become pregnant. Due to its negligible absorption orlistat does not have negative impact on cardiovascular system or other body systems. Orlistat is as beneficial as metformin in the treatment of polycystic ovarian syndrome. The effects of anti-obesity intervention with orlistat on microvascular endothelial function. Influence of orlistat on bone turnover and body composition. Orlistat improves endothelial function in obese adolescents a randomised trial. The effects of orlistat in patients with diabetes improvement in glycaemic control and weight loss. The present study refers to orlistat, sibutramine, and rimonabant.
Orlistat in polycystic ovarian syndrome reduces weight with improvement in lipid profile and pregnancy rates
Simultaneous use of orlistat and sibutramine occurred in six cases. However, side-effects were less with orlistat. However, those in orlistat group tolerated the drug well. In addition, subjects in orlistat group showed significant improvement in lipid profile. The role of orlistat combined with lifestyle changes in the management of overweight and obese patients with polycystic ovary syndrome. Orlistat is taken at mealtimes to prevent fat that is eaten in the meals from being broken down and absorbed by the body.
Is It Safe to Take Xenical While Pregnant?
Orlistat should be used alongside increased exercise and a reduced calorie, lower fat diet. If you take orlistat with a meal that is very high in fat you are more likely to experience digestive side effects such as wind, oily spotting from the rectum, sudden bowel motions, and soft, fatty or oily stools. If you are taking the pill for contraception you may need to use an additional method of contraception to prevent pregnancy, eg condoms, if you get severe diarrhoea while taking this medicine. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. The safety of orlistat during pregnancy has not been established.
Ask your doctor for advice if you think you could be pregnant while taking this medicine. The following are some of the side effects that are known to be associated with orlistat. You are less likely to experience digestive side effects if you follow the instructions on what to eat while taking orlistat and do not take it with meals that are high in fat. Talk to your doctor, nurse or pharmacist if you want any more information about the possible side effects of orlistat. Similarly, check with your doctor or pharmacist before taking any new medicines while taking orlistat, to make sure that the combination is safe. Orlistat may also reduce the absorption of certain medicines from the gut, for example those listed below, and so could make these less effective.
If you are taking medicines for diabetes, you may need an adjustment in your dose if you lose weight while taking orlistat. Orlistat is not recommended for use in combination with acarbose for diabetes. Orlistat can cause diarrhoea, which if severe, can reduce the absorption of oral contraceptive pills from the gut and thus make them less effective at preventing pregnancy. It should be used with caution during pregnancy and only if the benefits outweigh any possible risks to the developing baby. If you are taking orlistat with one of these medicines your doctor may need to do some extra monitoring to make sure your medicine is still effective. If you are taking the pill for contraception you may need to use an additional method of contraception, eg condoms, to prevent pregnancy, if you experience severe diarrhoea while taking this medicine.
It is unclear whether these cases were actually caused by orlistat or other factors. If you have these conditions or have had them in the past, talk with your healthcare provider before taking orlistat. Other drugs may interact with orlistat, including prescription and over-the-counter medicines, vitamins, and herbal products. Taking orlistat can make it harder for your body to absorb certain vitamins. Si bien su principio activo, el orlistat, logra la pérdida de peso, aparentemente también afectaría a los riñones, provocando daño renal.
You will need to discuss the benefits and risks of using sibutramine while pregnant. No embryotoxicity or teratogenicity was seen in animals that received orlistat at doses much higher than the recommended human dose. The disposition of orlistat appeared to be similar betweeormal weight and obese subjects. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Long-term systemic exposure of orlistat, a lipase inhibitor, and its metabolites in obese patients.
One-year treatment of obesity a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor. The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis. Orlistat-associated adverse effects and drug interactions a critical review. Evaluation of efficacy and safety of orlistat in obese patients. An integrated analysis of liver safety data from orlistat clinical trials.
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