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Si bien su principio activo, el orlistat, logra la pérdida de peso, aparentemente también afectaría a los riñones, provocando daño renal. Symptoms may include agitation confusion hallucinations coma fever fast or irregular heartbeat tremor excessive sweating incoordination rigid muscles blood pressure changes and nausea, vomiting, or diarrhea. This is only a brief summary of general information about sibutramine. This is only a brief summary of general information about this medicine. Although orlistat and sibutramine undoubtedly produce weight loss, the effect is modest.
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Orlistat does not cause cardiovascular side effects and may be particularly useful for obese people with pre-existing cardiovascular disease. Orlistat a review of its use in the management of obesity. Comparison of orlistat and sibutramine in an obesity management program efficacy, compliance, and weight regain after noncompliance. Other drugs may interact with orlistat, including prescription and over-the-counter medicines, vitamins, and herbal products. Orlistat works by blocking the enzyme that breaks down fats in your diet.
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Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Long-term systemic exposure of orlistat, a lipase inhibitor, and its metabolites in obese patients. One-year treatment of obesity a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor. The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis. Orlistat-associated adverse effects and drug interactions a critical review.
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Treatment with both amphetamine and orlistat had significant effect in reducing body weight, besides, supplementing diet with orlistat increase food intake. Treatment with both amphetamine and orlistat had significant effect in increasing insulin and glucose. Animals were sacrified under anesthesia with diethyl ether, and then blood was collected and refrigerated for one hour to clot. Plants were screened for their antilipase activity using ra- dioactive method, the study found that many plants can improve body weights and did not possess any lipase inhibitor effect.
These results indicate that there is no positive effect of orlistat, amphetamine or the two in combination on catalase activity. Administration of orlistat and amphetamine together did not have any effect. Orlistat is a reversible lipase inhibitor that acts by inhibiting the absorption of dietary fats, while amphetamine increased lipase. Normal-weight patients with bulimia nervosa have abused orlistat as a purging mechanism.
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