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The effect of the gastrointestinal lipase inhibitor, orlistat, on serum lipids and lipoproteins in patients with primary hyperlipidaemia. Treatment with orlistat reduces cardiovascular risk in obese patients. Randomized placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Influence of orlistat on the regulation of gallbladder contraction in man a randomized double-blind placebo-controlled crossover study. Retrospective population-based analysis of the dose-response fecal fat excretion relationship of orlistat iormal and obese volunteers. Comparison of the inhibition of dietary fat absorption by full versus divided doses of orlistat. Effect on dietary fat absorption of orlistat, administered at different times relative to meal intake. Metabolic profiles of minimally absorbed orlistat in obese/overweight volunteers.
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Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. Influence of dietary composition on the inhibition of fat absorption by orlistat. The effect of orlistat, an inhibitor of dietary fat absorption, on the pharmacokinetics of β-carotene in healthy volunteers. The effect of orlistat on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers.
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The influence of orlistat on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers. The influence of reduced dietary fat absorption induced by orlistat on the pharmacokinetics of digoxin in healthy volunteers. Effect of the lipase inhibitor orlistat on the pharmacokinetics of four different antihypertensive drugs in healthy volunteers. Lack of (interaction >= orlistat AND interaction <= oralcontraceptives. The effect of orlistat on the pharmacokinetics of phenytoin in healthy volunteers. The interaction of the lipase inhibitor orlistat with ethanol in healthy volunteers. A one-year trial to assess the value of orlistat in the management of obesity.
Pharmacokinetic evaluation of the possible interaction between selected concomitant medication and orlistat at steady state in healthy subjects. Obesity in transplant patients case report showing interference of orlistat with absorption of cyclosporine and review of literature. Effect of orlistat on blood cyclosporin concentration in an obese heart transplant patient. Reduction in blood cyclosporine concentrations by orlistat. Orlistat in the long-term treatment of obesity in primary care settings.
Orlistat a review of its use in the management of patients with obesity. Hypothyroidism in thyroid carcinoma follow-up orlistat may inhibit the absorption of thyroxine. Orlistat-associated adverse effects and drug interactions a critical review. Effects of orlistat, a lipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs amiodarone, fluoxetine, and simvastatin in healthy volunteers. Questions and answers orlistat and severe liver injury. Acute oxalate nephropathy associated with orlistat.
Orlistat-induced cutaneous leukocytoclastic vasculitis. Orlistat-induced bullous leukocytoclastic vasculitis. Orlistat prevents your body from absorbing the fat from the food you eat. Generic medicines must comply with exactly the same standards of quality, safety and efficacy as all medicinal products. It defines a period of time during which the generics applicant is restricted from applying to the medicines authorities for market authorisation. Generic medicines applications do not make use of any data from the originator registration file. Lipase, an enzyme found in the digestive tract, assists in breaking dietary fat down into smaller components so it can be stored for energy.
To gain optimal benefit, avoid the intake of food containing fat between meals, such as biscuits, chocolate and savoury snacks. The use of orlistat may be associated with renal stones in patients suffering from chronic kidney disease. In the stomach and the small intestines, certain enzymes called lipases extract fat from the food we eat, and help the body to store it as energy. Pharmacokinetic evaluation of the possible interaction between selected concomitant medications and orlistat at steady state in healthy subjects. Orilistat blocks the action of the enzyme in the body that normally breaks down fats. Orlistat blocks gastrointestinal lipases enzymes that digest fat. The body cannot use this dietary fat for energy or convert it into fat tissue.
Because some vitamins are fat soluble, the effect of orlistat is to reduce their body absorption. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases. The active ingredient orlistat works by preventing the absorption of some of the fat you eat. They are the natural effects of orlistat's fat-blocking action and are actually signs that the medication is working properly. Prescription orlistat is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease.
Orlistat is in a class of medications called lipase inhibitors. This generally occurs during the first weeks of treatment however, it may continue throughout your use of orlistat. There is not enough information to tell whether the liver damage was caused by orlistat. Orlistat may interfere with warfarin, cyclosporine, and levothyroxine.
Patients treated concomitantly with orlistat and levothyroxine should be monitored for changes in thyroid function. Alli orlistat has an extensive clinical history. Alli orlistat is used to help with weight loss and management when used with a diet that is low in fat. Alli orlistat like any other medication has risks and possible side effects associated with its use. In general, dietary supplements should only be taken under the supervision of your health care provider. Alli orlistat works by blocking the fat you eat and preventing your body from absorbing fat. No causal relationship or physiopathological (mechanism >= hepatitis AND mechanism <= orlistat)therapy has been established.