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The effect of the gastrointestinal lipase inhibitor, orlistat, on serum lipids and lipoproteins in patients with primary hyperlipidaemia. Treatment with orlistat reduces cardiovascular risk in obese patients. Randomized placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase.
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Influence of orlistat on the regulation of gallbladder contraction in man a randomized double-blind placebo-controlled crossover study. Retrospective population-based analysis of the dose-response fecal fat excretion relationship of orlistat iormal and obese volunteers. Comparison of the inhibition of dietary fat absorption by full versus divided doses of orlistat. Effect on dietary fat absorption of orlistat, administered at different times relative to meal intake. Metabolic profiles of minimally absorbed orlistat in obese/overweight volunteers. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers.
Influence of dietary composition on the inhibition of fat absorption by orlistat. The effect of orlistat, an inhibitor of dietary fat absorption, on the pharmacokinetics of β-carotene in healthy volunteers. The effect of orlistat on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. The influence of orlistat on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers.
The influence of reduced dietary fat absorption induced by orlistat on the pharmacokinetics of digoxin in healthy volunteers. Effect of the lipase inhibitor orlistat on the pharmacokinetics of four different antihypertensive drugs in healthy volunteers. Lack of (interaction >= orlistat AND interaction <= oralcontraceptives. The effect of orlistat on the pharmacokinetics of phenytoin in healthy volunteers. The interaction of the lipase inhibitor orlistat with ethanol in healthy volunteers.
A one-year trial to assess the value of orlistat in the management of obesity. Pharmacokinetic evaluation of the possible interaction between selected concomitant medication and orlistat at steady state in healthy subjects. Obesity in transplant patients case report showing interference of orlistat with absorption of cyclosporine and review of literature. Effect of orlistat on blood cyclosporin concentration in an obese heart transplant patient.
Reduction in blood cyclosporine concentrations by orlistat. Orlistat in the long-term treatment of obesity in primary care settings. Orlistat a review of its use in the management of patients with obesity. Hypothyroidism in thyroid carcinoma follow-up orlistat may inhibit the absorption of thyroxine. Orlistat-associated adverse effects and drug interactions a critical review. Effects of orlistat, a lipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs amiodarone, fluoxetine, and simvastatin in healthy volunteers.
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It's formulated to work only in your digestive system and should not affect your heart rate, your brain or cause sleeplessness. If you have missed several doses, please inform your doctor and follow the advice given to you. The use of orlistat may be associated with renal stones in patients suffering from chronic kidney disease. Increases in the levels of some liver enzymes may be found in blood tests, diverticulitis, gallstones, hepatitis inflammation of the liver, pancreatitis inflammation of the pancreas, skin blistering including blisters that burst, effects on clotting with anti-coagulants.
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