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These side effects result from orlistat's partial blockage of fat absorption in the intestine. Orlistat is unique in that does not affect the central nervous system to induce weight loss, but instead acts peripherally to prevent absorption of fat. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Although orlistat and sibutramine undoubtedly produce weight loss, the effect is modest. Orlistat does not cause cardiovascular side effects and may be particularly useful for obese people with pre-existing cardiovascular disease. Orlistat a review of its use in the management of obesity. Comparison of orlistat and sibutramine in an obesity management program efficacy, compliance, and weight regain after noncompliance.
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Treatment with both amphetamine and orlistat had significant effect in reducing body weight, besides, supplementing diet with orlistat increase food intake. Treatment with both amphetamine and orlistat had significant effect in increasing insulin and glucose. These results indicate that there is no positive effect of orlistat, amphetamine or the two in combination on catalase activity. Administration of orlistat and amphetamine together did not have any effect. Orlistat is a reversible lipase inhibitor that acts by inhibiting the absorption of dietary fats, while amphetamine increased lipase. Normal-weight patients with bulimia nervosa have abused orlistat as a purging mechanism.
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Patients with anorexia who purge are at much greater risk of developing serious medical complications. Effect of orlistat in obese patients with binge eating disorder. Effects of orlistat on fat-soluble vitamins in obese adolescents. Orlistat is used for managing obesity in overweight adults. The patriarch solemnly showed, may the lord dig you and let you to orlistat see all your patients.
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Treatment with orlistat reduces cardiovascular risk in obese patients. Randomized placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. Influence of orlistat on the regulation of gallbladder contraction in man a randomized double-blind placebo-controlled crossover study. Retrospective population-based analysis of the dose-response fecal fat excretion relationship of orlistat iormal and obese volunteers. Comparison of the inhibition of dietary fat absorption by full versus divided doses of orlistat.
Effect on dietary fat absorption of orlistat, administered at different times relative to meal intake. Metabolic profiles of minimally absorbed orlistat in obese/overweight volunteers. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. Influence of dietary composition on the inhibition of fat absorption by orlistat.
The effect of orlistat, an inhibitor of dietary fat absorption, on the pharmacokinetics of β-carotene in healthy volunteers. The effect of orlistat on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. The influence of orlistat on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers. The influence of reduced dietary fat absorption induced by orlistat on the pharmacokinetics of digoxin in healthy volunteers.
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Effect of orlistat on blood cyclosporin concentration in an obese heart transplant patient. Reduction in blood cyclosporine concentrations by orlistat. Orlistat in the long-term treatment of obesity in primary care settings. Orlistat a review of its use in the management of patients with obesity. Hypothyroidism in thyroid carcinoma follow-up orlistat may inhibit the absorption of thyroxine. Orlistat-associated adverse effects and drug interactions a critical review.
Effects of orlistat, a lipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs amiodarone, fluoxetine, and simvastatin in healthy volunteers. Questions and answers orlistat and severe liver injury. Acute oxalate nephropathy associated with orlistat. Orlistat-induced cutaneous leukocytoclastic vasculitis.
Orlistat-induced bullous leukocytoclastic vasculitis. Orlistat prevents your body from absorbing the fat from the food you eat. If you take more capsules than you have been told to take, or if someone else accidentally takes your medicine, contact a doctor, pharmacist or hospital as you may need medical attention. The use of orlistat may be associated with renal stones in patients suffering from chronic kidney disease. Xenical is not intended to be used in children. Xenical has no known effect on your ability to drive a car or operate machinery.
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